Rohit Bose MD PhD (Principal Investigator)
is a tenure-track assistant professor and practising genitourinary medical oncologist in the Departments of Anatomy, Medicine (Division of Hematology & Medical Oncology) and Urology. He is on the executive committee of the UCSF Benioff Initiative for Prostate Cancer Research, and a member of the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF BMS Graduate Program.
After his BSC honors thesis studying lymphocyte costimulation with Peter Bretscher, he investigated the interplay between signaling pathways and transcriptional control of epithelial architecture in Jeff Wrana's lab during his MD/PhD at the University of Toronto. He then did Internal Medicine Residency, Medical Research Track at Weill Cornell, followed by Medical Oncology Fellowship at Memorial Sloan Kettering Cancer Center. As a Fellow and Instructor there, he trained in Charles Sawyers' lab studying how transcription factors compete to initiate prostate cancer. Subsequently, he joined the UCSF faculty and the first lab members joined in 2019.
Arun Chandrakumar PhD (Postdoctoral Scholar)
During his doctoral work in Dr Robert Rottapel's lab at the University of Toronto, he identified new substrates of an ADP-ribose dependent protein degradation system regulated by Tankyrase and RNF146. He showed that these substrates (SH3BP5 and SH3BP5L) are homologous guanine exchange factors for the Rab11a GTPase. He characterized the role of this degradation pathway during epithelial lumenogenesis using CRISPR and confocal microscopy where Tankyrase inhibits SH3BP5/SH3BP5L during lumen formation and RNF146 acts as a positive regulator of lumen formation by regulating Tankyrase stability.
Woogwang Sim PhD (Postdoctoral Scholar)
During his time as team leader of the AI Lab at OncoCross and prior doctoral work in Jungsul Lee's lab at KAIST, he developed expertise in research investigating novel biomarkers of cancer occurrence and/or progression to improve the clinical outcome of cancer patients based on multi-scale biomedical data.
Ruhollah Moussavi-Baygi PhD (co-mentored Postdoctoral Scholar with Goodarzi Lab)
During his time in the Goodarzi lab, and prior graduate work with Mohammad Mofrad at UC Berkeley, he developed interests in computational cancer genetics & evolution, nucleo-cytoplasmic dynamics & deep learning.
Matthew J Ryan (MD/PhD candidate, MSTP member)
Previously, he completed a senior honors thesis at Tufts in the lab of Krishna Kumar, studying the synthesis and cellular activity of lipid-anchored estrogen receptor antagonists and siallic acid analogues. Following graduation, he worked at the Broad Institute of MIT and Harvard in the lab of Stuart Schreiber, interrogating the susceptibility of cancer cells in a high-mesenchymal, therapy-resistant state to programmed cell death by ferroptosis. In our lab, his interests include the Genomic Burden of Advanced Prostate Cancers and Therapeutic Implications.
Tejasveeta Nadkarni MS (Research Specialist and Lab Manager)
received her Master of Science in Biotechnology at NYU. She went on to work as a Research Technician, first at Weill Cornell Medicine, then at Memorial Sloan Kettering Cancer Center. During the latter, she has developed expertise studying tumor suppressors that function independently of androgen signaling to drive resistance in castrate-resistant prostate cancer.
Melita Haryono (Research Specialist)
received her Bachelors in Biochemistry/Chemistry at University of California, San Diego. There, she had volunteered at the Bloodgood lab studying ER voltage driven cellular activity in dissociated neuron cultures.
Ivy Fang (Research Specialist)
received her bachelor's degree in Cell and Molecular Biology at San Francisco State University. Previously, she has developed her understanding in the role of chemokine receptors in cancer health disparities and T cell differentiation in the tumor microenvironment.
Lab Alumni
Peng Jin PhD Prior Postdoctoral Scholar where now
Lisanne Vermeer Prior MSc Candidate at Utrecht University where Now
Kharishma Patel Prior MSc Candidate at Utrecht University Where Now
Andy Dang Prior Administrative Analyst Where Now
Team Building
Halloween 2021
End of Sam's Rotation
We are hiring:
post-doctoral or clinical fellows
graduate students
research specialists / technicians
click here to join the bose lab