Publications and Active Projects at the Bose Lab

Bose R, Karthaus W, Armenia J, Abida W, Iaquinta P, Wongvipat J, Wasmuth E, Shah N, Doran M, Wang P, Sullivan P, Patruno A, International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers C. ERF mutations reveal balance of positive and negative ETS factors controlling prostate cancer. Nature, 546, pp. 671-675 (2017). 

Highlighted in:

Adams E, Karthaus W, Hoover E, DiLoreto R, Liu D, Liu Y, Watson P, Davicioni E, Sboner A, Barberi C, Bose R, Leslie C, Sawyers C. Oncogenic mutations alter the chromatin landscape, perturb luminal differentiation programs, and confer distinct prostate cancer phenotypes.  In revision.

Kelly W, Godwin J, Hoffman-Censits J, Knudsen K, De Leeuw R, Leiby B, Southwell T, Hubert C, Smith D, Chatta G, Agahalar J, Scher H, Bose R, Autio K, Abida W, Slovin S, The Prostate Cancer Clinical Trials Consortium. c15-153: Randomized phase IB/II study of enzalutamide with and without ribociclib in patients with metastatic castrate resistant, chemotherapy naïve prostate cancer that retains RB expressionJournal of Clinical Oncology. 20 (2018). 

Silvestri C, Bose R, Attisano L and Wrana J. Functioning of Transmembrane Receptors in Signaling Mechanisms: Cell Signaling CollectionTGF β Signal Transduction. 70, pp. 521-532 (2010). 

Bose R*, Narimatsu M*, Pye M, Zhang L, Miller B, Ching P, Sakuma, R, Luga V, Roncari L, Attisano L, Wrana J. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell, 137, pp. 295-307 (2009).  *co-first authors.

Highlighted in:

Viloria-Petit A, David L, Jia J, Erdemir T, Bane A, Pinnaduwage D, Roncari L, Narimatsu M, Bose R, Moffat J, Wong J, Kerbel R, O'Malley F, Andrulis I, Wrana J. A role for the TGFβ-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci USA, 106, pp.14028-14033 (2009).  

Wang H, Ogunjimi A, Zhang Y, Ozdamar B, Bose R and Wrana, J. Degradation of RhoA by Smurf1 ubiquitin ligase. Methods in enzymology, 406, pp.437-447 (2006).

Le Roy C, Bose R and Wrana J. Trafficking of Serine/Threonine Kinase Receptors and Smad Activation. Smad Signal Transduction. 9, pp. 177-191 (2006).

Bose R*, Ozdamar B*, Barrios-Rodiles M, Wang H, Zhang Y and Wrana J. Regulation of the polarity protein Par6 by TGFß receptors controls epithelial cell plasticity. Science, 307, pp.1603-1609 (2005).  *co-first authors.  

Highlighted in: 

Barrios-Rodiles M, Brown K, Ozdamar B, Bose R, Liu Z, Donovan R, Shinjo F, Liu Y, Dembowy J, Taylor I,Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana J. High-throughput mapping of a dynamic signaling network in mammalian cells. Science, 307, pp.1621-1625 (2005).  

Highlighted in:   

Bose R, Hwang S. Income and spending patterns among panhandlers. CMAJ, 167, pp.477-479 (2002).  

Bose R, Ahmad A, Dicks A, Kayser K, McClelland R. Spectroscopic characterization by laser flash photolysis of electrophilic intermediates derived from 4-aminostilbenes. Stilbene “nitrenium” ions and quinone methide imines. Journal of the Chemical Society, Perkin Transactions 2, pp.1591-1600 (1999). 

 

External Funding

We are deeply grateful for receiving funding for the above projects from:

 

 

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& Dr. Elliot Abramowitz

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Selected Awards

Rohit Bose MD PhD, Principal Investigator rohit bose CV

 

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